2022
BNS Program Newsletter
BNS Program Faculty Publications
Dr. Jeff Grimm
Dr. Jeffrey Grimm, director of Western Washington University’s behavioral neuroscience program (BNS), operates and supervises the university’s Neurobiology of Relapse lab. Daily laboratory work is primarily conducted by student lab technicians from the psychology and BNS departments, while Dr. Grimm oversees study design and writing.
Recent Papers List
Grimm JW, North K, Hopkins M, Jiganti K, McCoy A, Šulc J, MacDougall D, Sauter F. Sex differences in sucrose reinforcement in Long-Evans rats. Biol Sex Differ. 2022 Jan 11;13(1):3. doi: 10.1186/s13293-022-00412-8. PubMed PMID: 35016712; PubMed Central PMCID: PMC8753819.
Venniro M, Reverte I, Ramsey LA, Papastrat KM, D’Ottavio G, Milella MS, Li X, Grimm JW, Caprioli D. Factors modulating the incubation of drug and non-drug craving and their clinical implications. Neurosci Biobehav Rev. 2021 Dec;131:847-864. doi: 10.1016/j.neubiorev.2021.09.050. Epub 2021 Sep 28. Review. PubMed PMID: 34597716; PubMed Central PMCID: PMC8931548.
Margetts-Smith G, Macnaghten AI, Brebner LS, Ziminski JJ, Sieburg MC, Grimm JW, Crombag HS, Koya E. Acute, but not longer-term, exposure to environmental enrichment attenuates Pavlovian cue-evoked conditioned approach and Fos expression in the prefrontal cortex in mice. Eur J Neurosci. 2021 Apr;53(8):2580-2591. doi: 10.1111/ejn.15146. Epub 2021 Mar 2. PubMed PMID: 33565633; PubMed Central PMCID: PMC8085094.
Dr. Josh Kaplan
The Kaplan lab studies the developmental consequences and therapeutic efficacy of cannabis in pre-clinical rodent models of disease and psychological disorders. To do this, we employ behavioral, genetic, pharmacological, and electrophysiology techniques coupled with novel passive inhalation methods that mimic human use patterns. We aim to optimize cannabis’ medicinal benefits, minimize side effects, and better understand its impact on the developing brain.
Recent Papers List
Kaplan, J.S., Wagner, J.K., Reid, K., McGuinness, F., Arvila, S., Brooks, M., Stevenson, H., Jones, J., Risch, B., McGillis, T., Budinich, R., Gambell, E., & Predovich, B. (2021). Cannabidiol exposure during the mouse adolescent period is without harmful behavioral effects on locomotor activity, anxiety, and spatial memory. Frontiers in Behavioral Neuroscience.
Wagner, J.K., Gambell, E., Gibbons, T., Martin, T.J. & Kaplan, J.S. (Submitted and under review). Sex differences in the anxiolytic properties of common cannabis terpenes, linalool and β-myrcene, in mice.
Staben, J., Koch, M. , Reid, K. , Muckerheide, J., Gilman, L. , McGuinness, F. , Kiesser, S., Oswald, I.W.H., Koby, K.A., Martin, T.J., & Kaplan, J.S. (Submitted and under review). Cannabidiol and Cannabis-Inspired Terpene Blends Have Acute Prosocial Effects in the BTBR Mouse Model of Autism Spectrum Disorder.
Aychman, M.M., Goldman, D.L., & Kaplan, J.S. (Submitted and under review). Cannabidiol’s Neuroprotective Properties and Potential Treatment of Traumatic Brain Injuries
Westenbroek, R., Kaplan, J.S., Viray, K., & Stella, N. (Submitted and under review). The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome.
Dr. Jackie Rose
Dr. Rose employs several approaches to gain insight into how neurons are uniquely adapted to modify themselves following a change in stimulus input. Research in the Rose lab utilizes the microscopic C. elegans model system to investigate processes at the single-neuron level within an intact animal model. Dr. Rose also employs dissociated hippocampal neuron cultures to observe protein redistribution and aggregation following induced activity.
Recent Papers List
JK Rose, KM Scaplen, S Mizumori, A Roberts. (2022) Editorial: Modulation of Behavioral Outcomes by Conditioning Competing States, Valences, or Responses. Frontiers in Behavioral Neuroscience, doi: 10.3389/fnbeh.2022.959704
Pribic, M.R., *Black, A.H., *Beale, A.D., Gauvin, J.A., Chiang, L.N. & Rose, J.K. (2022) Association of Two Opposing Responses Results in the Emergence of a Novel Conditioned Response. Frontiers in Behavioral Neuroscience, 16. doi: 10.3389/fnbeh.2022.852266
ZT Fitzgerald, JK Rose. (2020) Locally-Induced CaMKII Translocation Requires Nucleotide Binding. Frontiers in synaptic neuroscience.
*Fitzgerald, Z. T., & Rose, J. K. (2020).Locally-Induced CaMKII Translocation Requires Nucleotide Binding. Frontiers in Synaptic Neuroscience, 12, 4. doi: 10.3389/fnsyn.2020.00004
Meneely, P. M., Dahlberg, C. L., & Rose, J. K. (2019). Working with worms: Caenorhabditis elegans as a model organism. Current Protocols Essential Laboratory Techniques, 19(1), e35.
Dr. Kelly Jantzen
In the Human Cognition and Neural Dynamics Lab (HCND), we seek to understand the link between complex human behavior and brain dynamics. It is widely recognized that human behavior, in all its rich forms and with all its inherent variability, arises primarily from the interplay between distributed brain regions. At the HCND, we use electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to both measure and influence the electrical activity of the brain with the goal of identifying and quantifying neural signatures of human behavior and ability.
Recent Papers List
Jantzen, KJ, McNamara, N., Harris, A., Schubert, A., Brooks, M., Seifert, M., Symons, L. (2022). Contrast reversal of the iris and sclera increases the face sensitive N170. Frontiers in Human Neuroscience, 16:987212. doi: 10.3389/fnhum.2022.987217.
Martinez, S., Hahn, A., Leytze, M., Lucier, K., Amir-Brownstein, B., Jantzen, K.J. (2020) Preferential attention to same- and other-ethnicity infant faces does not fully overcome the Other Race Effect. Ethology. DOI:10.1111/eth.12987
Behmer, L.P., Jantzen, K.J., Martinez, S.*, Walls, R.**, Amir-Brownstein, E.**, Jaye, A.**, Leytze, M.**, Lucier, K.**, Crump, M. (2018). Parallel regulation of past, present, and future actions during sequencing. Journal of Experimental Psychology: Human Perception and Performance, 44(8), 1147-1152.
Dr. Mike Mana
Neural Substrates of Cognition Lab
Recent Papers List
Finlay, J.M., Jedema, H.P., Rabinovic, A.D., Mana, M.J., Zigmond, M.J. and Sved, A.F. (1997), Impact of Corticotropin-Releasing Hormone on Extracellular Norepinephrine in Prefrontal Cortex After Chronic Cold Stress. Journal of Neurochemistry, 69: 144-150. https://doi.org/10.1046/j.1471-4159.1997.69010144.x
Mumby, D. G., Mana, M. J., Pinel, J. P. J., David, E., & Banks, K. (1995). Pyrithiamine-induced thiamine deficiency impairs object recognition in rats. Behavioral Neuroscience, 109(6), 1209–1214. https://doi.org/10.1037/0735-7044.109.6.1209
G. Di Scala, Michael J. Mana, W.J. Jacobs, A.G. Phillips, Evidence of Pavlovian conditioned fear following electrical stimulation of the periaqueductal grey in the rat, Physiology & Behavior, Volume 40, Issue 1,
1987, Pages 55-63, ISSN 0031-9384, https://doi.org/10.1016/0031-9384(87)90185-5 .
Dr. Jeff Carroll
Work in the Carroll lab is focused on understanding whole body symptoms of Huntington’s Disease, using a genetic mouse model. We are particularly interested in the role that brain-body cross talk plays in the development of HD symptoms in our system. Dr. Carroll is also engaged in education efforts targeting the Huntington’s Disease community, including HD Buzz, and the effects these educational efforts have on community member’s decision making.
Recent Papers List
Ament S.A., Pearl J.R., Cantle J.P., Bragg R.M., Skene P.J., Coffey S.R., Bergey D.E., Wheeler V.C., MacDonald M.E., Baliga N.S., Rosinski J., Hood L.E., Carroll J.B., Price N.D., 2018. Transcriptional regulatory networks underlying gene expression changes in Huntington’s disease. Mol Syst Biol. 14(3):e7435. doi: 10.15252/msb.20167435. [Journal]
Kovalenko, M., Milnerwood, A., Giordano, J., St Claire, J., Guide, J.R., Stromberg, M., Gillis, T., Sapp, E., DiFiglia, M., MacDonald, M.E., Carroll, J.B., Lee J.M., Tappan, S., Raymond, L., Wheeler, V.C., 2018. HttQ111/+ Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction. J Huntingtons Dis.;7(1):17-33. doi: 10.3233/JHD-170282. [Journal]
Minnig, S., Bragg, R.M., Tiwana, H.S., Solem, W.T., Hovander, W.S., Vik, E.M.S., Hamilton, M., Legg, S.R.W., Shuttleworth, D.D., Coffey, S.R., Cantle, J.P., Carroll, J.B., 2018. Early Detection of Apathetic Phenotypes in Huntington’s Disease Knock-in Mice Using Open Source Tools. Scientific Reports 8, Article number: 2304. [Journal]