Publications

  1. Yang, M.; Zinkgraf, M.; Fitzgerald-Cook, C.; Harrison, B. R.; Putzier, A.; Promislow, D. E. L.; Wang, A. M. Using Drosophila to Identify Naturally Occurring Genetic Modifiers of Amyloid Beta 42- and Tau-Induced Toxicity. G3 2023, 13 (9). https://doi.org/10.1093/g3journal/jkad132
  2. Urfer, S. R.; Latimer, C. S.; Ladiges, W.; Keene, C. D.; Benbow, S.; Harrison, B.; Promislow, D. E. L.; Kaeberlein, M.; Kraemer, B. C.; Wang, A.; Guscetti, F.; Darvas, M. Cross Species Application of Quantitative Neuropathology Assays Developed for Clinical Alzheimer’s Disease Samples. Pathobiology of Aging & Age-related Diseases 2019, 9 (1), 1657768. https://doi.org/10.1080/20010001.2019.1657768
  3. Wang, A.; Mouser, J.; Pitt, J.; Promislow, D.; Kaeberlein, M. Rapamycin Enhances Survival in a Drosophila Model of Mitochondrial Disease. Oncotarget 2016, 7 (49), 80131–80139. https://doi.org/10.18632/oncotarget.12560
  4. McCormick, M. A.; Delaney, J. R.; Tsuchiya, M.; Tsuchiyama, S.; Shemorry, A.; Sim, S.; Chou, A. C.-Z.; Ahmed, U.; Carr, D.; Murakami, C. J.; Schleit, J.; Sutphin, G. L.; Wasko, B. M.; Bennett, C. F.; Wang, A. M.; Olsen, B.; Beyer, R. P.; Bammler, T. K.; Prunkard, D.; Johnson, S. C.; Pennypacker, J. K.; An, E.; Anies, A.; Castanza, A. S.; Choi, E.; Dang, N.; Enerio, S.; Fletcher, M.; Fox, L.; Goswami, S.; Higgins, S. A.; Holmberg, M. A.; Hu, D.; Hui, J.; Jelic, M.; Jeong, K.-S.; Johnston, E.; Kerr, E. O.; Kim, J.; Kim, D.; Kirkland, K.; Klum, S.; Kotireddy, S.; Liao, E.; Lim, M.; Lin, M. S.; Lo, W. C.; Lockshon, D.; Miller, H. A.; Moller, R. M.; Muller, B.; Oakes, J.; Pak, D. N.; Peng, Z. J.; Pham, K. M.; Pollard, T. G.; Pradeep, P.; Pruett, D.; Rai, D.; Robison, B.; Rodriguez, A. A.; Ros, B.; Sage, M.; Singh, M. K.; Smith, E. D.; Snead, K.; Solanky, A.; Spector, B. L.; Steffen, K. K.; Tchao, B. N.; Ting, M. K.; Vander Wende, H.; Wang, D.; Welton, K. L.; Westman, E. A.; Brem, R. B.; Liu, X.-G.; Suh, Y.; Zhou, Z.; Kaeberlein, M.; Kennedy, B. K. A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab. 2015, 22 (5), 895–906. https://doi.org/10.1016/j.cmet.2015.09.008
  5. Burman, J. L.; Itsara, L. S.; Kayser, E.-B.; Suthammarak, W.; Wang, A. M.; Kaeberlein, M.; Sedensky, M. M.; Morgan, P. G.; Pallanck, L. J. A Drosophila Model of Mitochondrial Disease Caused by a Complex I Mutation That Uncouples Proton Pumping from Electron Transfer. Dis. Model. Mech. 2014, 7 (10), 1165–1174. https://doi.org/10.1242/dmm.015321
  6. Delaney, J. R.; Murakami, C.; Chou, A.; Carr, D.; Schleit, J.; Sutphin, G. L.; An, E. H.; Castanza, A. S.; Fletcher, M.; Goswami, S.; Higgins, S.; Holmberg, M.; Hui, J.; Jelic, M.; Jeong, K.-S.; Kim, J. R.; Klum, S.; Liao, E.; Lin, M. S.; Lo, W.; Miller, H.; Moller, R.; Peng, Z. J.; Pollard, T.; Pradeep, P.; Pruett, D.; Rai, D.; Ros, V.; Schuster, A.; Singh, M.; Spector, B. L.; Wende, H. V.; Wang, A. M.; Wasko, B. M.; Olsen, B.; Kaeberlein, M. Dietary Restriction and Mitochondrial Function Link Replicative and Chronological Aging in Saccharomyces Cerevisiae. Exp. Gerontol. 2013, 48 (10), 1006–1013. https://doi.org/10.1016/j.exger.2012.12.001
  7. Delaney, J. R.; Chou, A.; Olsen, B.; Carr, D.; Murakami, C.; Ahmed, U.; Sim, S.; An, E. H.; Castanza, A. S.; Fletcher, M.; Higgins, S.; Holmberg, M.; Hui, J.; Jelic, M.; Jeong, K.-S.; Kim, J. R.; Klum, S.; Liao, E.; Lin, M. S.; Lo, W.; Miller, H.; Moller, R.; Peng, Z. J.; Pollard, T.; Pradeep, P.; Pruett, D.; Rai, D.; Ros, V.; Schleit, J.; Schuster, A.; Singh, M.; Spector, B. L.; Sutphin, G. L.; Wang, A. M.; Wasko, B. M.; Vander Wende, H.; Kennedy, B. K.; Kaeberlein, M. End-of-Life Cell Cycle Arrest Contributes to Stochasticity of Yeast Replicative Aging. FEMS Yeast Res. 2013, 13 (3), 267–276. https://doi.org/10.1111/1567-1364.12030
  8. Wang, A. M.; Miyata, Y.; Klinedinst, S.; Peng, H.-M.; Chua, J. P.; Komiyama, T.; Li, X.; Morishima, Y.; Merry, D. E.; Pratt, W. B.; Osawa, Y.; Collins, C. A.; Gestwicki, J. E.; Lieberman, A. P. Activation of Hsp70 Reduces Neurotoxicity by Promoting Polyglutamine Protein Degradation. Nat. Chem. Biol. 2013, 9 (2), 112–118. https://doi.org/10.1038/nchembio.1140
       —Featured as a Research Highlight in Nature Reviews Drug Discovery 12, 102 (February 2013)
  9. Murakami, C.; Delaney, J. R.; Chou, A.; Carr, D.; Schleit, J.; Sutphin, G. L.; An, E. H.; Castanza, A. S.; Fletcher, M.; Goswami, S.; Higgins, S.; Holmberg, M.; Hui, J.; Jelic, M.; Jeong, K.-S.; Kim, J. R.; Klum, S.; Liao, E.; Lin, M. S.; Lo, W.; Miller, H.; Moller, R.; Peng, Z. J.; Pollard, T.; Pradeep, P.; Pruett, D.; Rai, D.; Ros, V.; Schuster, A.; Singh, M.; Spector, B. L.; Vander Wende, H.; Wang, A. M.; Wasko, B. M.; Olsen, B.; Kaeberlein, M. pH Neutralization Protects against Reduction in Replicative Lifespan Following Chronological Aging in Yeast. Cell Cycle 2012, 11 (16), 3087–3096. https://doi.org/10.4161/cc.21465
  10. Yu, Z.; *Wang, A. M.; Adachi, H.; Katsuno, M.; Sobue, G.; Yue, Z.; Robins, D. M.; Lieberman, A. P. Macroautophagy Is Regulated by the UPR-Mediator CHOP and Accentuates the Phenotype of SBMA Mice. PLoS Genet. 2011, 7 (10), e1002321. https://doi.org/10.1371/journal.pgen.1002321
  11. *Wang, A. M.; Morishima, Y.; Clapp, K. M.; Peng, H.-M.; Pratt, W. B.; Gestwicki, J. E.; Osawa, Y.; Lieberman, A. P. Inhibition of hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation. J. Biol. Chem. 2010, 285 (21), 15714–15723. https://doi.org/10.1074/jbc.M109.098806
  12. Yu, Z.; Wang, A. M.; Robins, D. M.; Lieberman, A. P. Altered RNA Splicing Contributes to Skeletal Muscle Pathology in Kennedy Disease Knock-in Mice. Dis. Model. Mech. 2009, 2 (9-10), 500–507. https://doi.org/10.1242/dmm.003301
  13. Morishima, Y.; Wang, A. M.; Yu, Z.; Pratt, W. B.; Osawa, Y.; Lieberman, A. P. CHIP Deletion Reveals Functional Redundancy of E3 Ligases in Promoting Degradation of Both Signaling Proteins and Expanded Glutamine Proteins. Hum. Mol. Genet. 2008, 17 (24), 3942–3952. https://doi.org/10.1093/hmg/ddn296
  14. Bergman, C. M.; Pfeiffer, B. D.; Rincón-Limas, D. E.; Hoskins, R. A.; Gnirke, A.; Mungall, C. J.; Wang, A. M.; Kronmiller, B.; Pacleb, J.; Park, S.; Stapleton, M.; Wan, K.; George, R. A.; de Jong, P. J.; Botas, J.; Rubin, G. M.; Celniker, S. E. Assessing the Impact of Comparative Genomic Sequence Data on the Functional Annotation of the Drosophila Genome. Genome Biol. 2002, 3 (12), RESEARCH0086. https://doi.org/10.1186/gb-2002-3-12-research0086

* denotes co-first authorship